Neonatal Hyperbilirubinemia Calculator - AAP 2025 & NICE Guidelines

📋 Patient Information

Gestational Age at Birth

weeks

days

Date and Time of Birth

Current Date and Time (or Time of Bilirubin Test)

Total Serum Bilirubin (TSB)

Postnatal Age (Calculated)

⚠️ Neurotoxicity Risk Factors (AAP 2025)

Select any applicable hyperbilirubinemia neurotoxicity risk factors:

Isoimmune hemolytic disease (ABO/Rh incompatibility with positive DAT) G6PD deficiency Asphyxia (Apgar 0-4 at 5 min OR pH <7.0 OR base deficit>10) Significant lethargy / Sepsis Albumin < 3.0 g/dL (if measured) Clinical instability in previous 24 hours

No neurotoxicity risk factors selected

📈 Results

AAP 2025 Guidelines

Based on AAP 2022 Revision | For infants ≥35 weeks gestational age

Phototherapy Threshold

mg/dL

Exchange Transfusion Threshold

mg/dL

Patient's Bilirubin Level

Recommendation

Enter patient data to see recommendations

NICE Guidelines (CG98)

For infants ≥23 weeks gestational age

Phototherapy Threshold

μmol/L

Exchange Transfusion Threshold

μmol/L

Patient's Bilirubin Level

Recommendation

Enter patient data to see recommendations

Guidelines Comparison

Side-by-side comparison of AAP 2022 and NICE thresholds

Parameter	AAP 2025	NICE

📋 Clinical Actions

Calculate thresholds to see recommended clinical actions

ℹ️ Additional Information

AAP 2025 Key Points:

Thresholds are based on gestational age and neurotoxicity risk factors
Updated thresholds for safer management
Applies to infants ≥35 weeks gestational age
Risk factors lower the treatment threshold

NICE Guidelines Key Points:

Based on gestational age-specific treatment threshold graphs
Applies to infants from 23 weeks gestational age
Uses linear interpolation between age points
Measured in μmol/L (1 mg/dL = 17.1 μmol/L)

When to Escalate:

TSB approaching exchange transfusion threshold
TSB rising rapidly (>0.2 mg/dL/hour or >8.5 μmol/L/hour)
Signs of acute bilirubin encephalopathy
TSB not decreasing despite intensive phototherapy